Brand Focus, Ingredient Focus, Skin Care Ingredients, Vitamins For The Skin

Tetrahexyldecyl Ascorbate


Lipid Soluble Vitamin C – Tetrahexyldecyl Ascorbate

The Best Topical Vitamin C For Your Skin

I have written a fair amount on Vitamin C and its numerous benefits for the skin as can be seen with the following blog articles: Vitamin C Serum, Vitamin C Quick Reference Guide, Vitamin C in Skin Care Products and Why Use Vitamin C in Your Skin Regime. All of these articles can be found at: Vitamins For The Skin.

So the question is how many more articles can we write on Vitamin C and the answer very simply is not many more. All its benefits, uses and recommended products are mentioned in the above blog articles but I thought considering we are running a Dermaquest C Infusion promotion this month we should visit the unique ingredient that is being used in the C Infusion Serum: TETRAHEXYLDECYL ASCORBATE.

What Is Tetrahexyldecyl Ascorbate?

“Tetrahexyldecyl ascorbate is a form of vitamin C that’s been modified to be more lipid soluble.” -Dr Alek Nikolic

This modification allows it to better penetrate the skin. The problem with most topical forms of vitamin C is they’re water soluble and can’t make it through the lipid-rich skin barrier to reach the dermis of skin where they could have maximal benefits. Tetrahexyldecyl ascorbate is able to successfully penetrate the epidermis and move to the layer underneath called the dermis. It’s in the dermis that collagen, a protein that gives skin its youthful firmness and ability to resist wrinkles, is made.

Why Choose a Skin Care Product with Tetrahexyldecyl Ascorbate?

In my opinion and looking at new study results this should be our go to topical Vitamin C ingredient.

“The best, most stable, non-acidic form of Vitamin C is Tetrahexyldecyl Ascorbate (abbreviated THDA or THD Ascorbate).” – Dr Alek Nikolic

Tetrahexyldecyl Ascorbate Summary of Skin Effects:

  • An oil-soluble form of Vitamin C that can penetrate the lipid bilayer
  • Retained in the epidermis and dermis (whereas Ascorbic Acid passes through), forming a reservoir of Vitamin C
  • Its antioxidant action is 80 times longer than Ascorbic Acid because it is a slower free radical scavenger
  • It has a two-year stability

Common Forms of Vitamin C:

  • Ascorbic Acid (L-Ascorbic Acid)
  • Ascorbyl Palmitate
  • Sodium Ascorbate
  • Sodium Ascorbyl Phosphate
  • Magnesium Ascorbyl Phosphate (MAP)
  • Tetrahexyldecyl Ascorbate (THDA) (also denoted Ascorbyl Tetraisopalmitate)
  • Ascorbyl Glucoside
  • Ascorbyl Glucosamine
  • Ascorbyl Methylsilanol Pectinate

I hope you found the article on Tetrahexyldecyl Ascorbate interesting and valuable and that it gave you a new insight in the different types of vitamin C that are available and their specific strengths and weaknesses.

Kind regards

Dr Alek Nikolic

Some Interesting Facts On Vitamin C

  1. There are different types of Vitamin C used by manufacturers in skin care products and it is important to choose the right ingredient for your skin to prevent sensitivity.
  2. Different types have different levels of effectiveness and stability.
  3. The concentration of the vitamin C determines effectiveness
  4. The higher the concentration the higher the chance of a skin reaction (this is reduced with lipid soluble types).
  5. Pure Vitamin C is Ascorbic Acid, also called L-ascorbic acid.
  6. L-ascorbic acid is an acidic formof Vitamin C, and it is water-soluble.
  7. Ascorbic Acid is the bioavailable form needed for collagen synthesis.
  8. All other forms of Vitamin C including lipid soluble ones such as Tetrahexyldecyl Ascorbate need to be converted to Ascorbic Acid inside skin cells.
  9. In skin care products it is more common to see the derivativesof Vitamin C such as water-soluble or oil-soluble forms of Ascorbic Acid.


  1. An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin. Herndon JH Jr, Jiang LI, Kononov T, Fox T. J Drugs Dermatol. 2016 Apr;15(4):476-82.
  2. An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin. Herndon JH Jr, Jiang L, Kononov T, Fox T. J Drugs Dermatol. 2015 Jul;14(7):699-704.
  3. Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation. Makino ET, Mehta RC, Banga A, Jain P, Sigler ML, Sonti S. J Drugs Dermatol. 2013 Mar;12(3):s16-20.
  4. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Fitzpatrick RE, Rostan EF. Dermatol Surg. 2002 Mar;28(3):231-6.

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About Dr Alek Nikolic

Dr Alek Nikolic was born in South Africa and received his MBBCh (Wits) in 1992 and in 2000 he received his MBA (UCT). He has been in private practice for 24 years and is the owner of Aesthetic Facial Enhancement, which has offices in Cape Town. Dr Nikolic specialises in aesthetic medicine and is at the forefront of the latest developments in his field. He is very driven and has lectured extensively and has performed live demonstrations throughout South Africa and Internationally including Bangkok, Rome, Paris, Monte Carlo, Prague, and Warsaw. Dr Nikolic’s focus is on skin care, skin ingredients and cosmetic dermatology treatments such as lasers, chemical peels, Botox, and Dermal Fillers. He has performed over 20 000 procedures to date and as such is responsible for training numerous medical practitioners both in South Africa and internationally. Dr Nikolic is one of the founding members of the South African Allergan Medical Aesthetic Academy and chaired its inaugural launch in 2012. The Allergan Academy provides essential training to keep up with the latest technology in aesthetics. Dr Nikolic holds the advisory position of Allergan Local Country Mentor in Facial Aesthetics and is the Allergan Advanced Botox and Dermal Filler Trainer. He is Vice President of the Aesthetic and Anti-Aging Medicine Society of South Africa (AAMSSA) and is an Associate Member of the American Society of Laser Medicine and Surgery (ASLMS).

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