SKINCEUTICALS Metacell Renewal B3

(24 customer reviews)


SKINCEUTICALS Metacell Renewal B3

Moisturiser. Pigmentation & anti-aging.

SkinCeuticals Metacell Renewal B3 is clinically shown to increase cell turnover, boost hydration volume, reclarify tone, and retighten skin’s surface. Early symptoms of photoageing present as a range of visible skin concerns: lack of vitality, uneven skin tone, blotchiness, wrinkles, and loss of natural elasticity in skin. While these symptoms show up at different intensities, they have a multiplicative effect, and sum up to create a prematurely-aged appearance. Metacell Renewal B3 is specifically formulated with a high-concentration cocktail of multi-corrective actives to address early symptoms of photoageing. This comprehensive emulsion is formulated with niacinamide, a tri-peptide concentrate, and pure glycerin in an advanced patent-pending delivery system for proven penetration in skin

Size: 50 ml

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Skin results and statements are based on clinical trials performed by the brand and individual results may vary.



How to use

How to use

Apply twice daily to clean face, neck, and chest.

Features & Benefits

Features & Benefits

Early symptoms of photoaging are linked to biological causes that affect all layers of the skin. Rough, dull texture and dehydration are symptoms that affect the stratum corneum, while discoloration affects the epidermis, and blotchiness, skin slackening, and static and fine lines affect the dermis. Lifestyle and genetics can cause a multiplicative effect of these symptoms, which can appear simultaneously and in different intensities.


Metacell Renewal B3, with its multi-corrective benefits, utilizes a synergistic combination of high-concentration ingredients selected to specifically address early symptoms of photoaging. This unique formulation boasts a patent-pending delivery system that increases penetration of key active ingredients without compromising the skin barrier.

5% Niacinamide (with a patent-pending delivery system)

  • Stimulates epidermal cell turnover
  • Reduces localized discoloration
  • Strengthens skin’s moisture barrier
  • Fortifies skin’s matrix

2.5% Tightening Tri-Peptide Concentrate

  • Supports natural hyaluronic acid synthesis
  • Enhances skin’s firmness to tighten and support the skin

15% Pure Glycerin

  • Powerful humectant
  • Formulated to deliver intense hydration without a tacky feel
  • Pro-penetrant (enhanced delivery system)

Fresh Emulsion

Unique water-break formulation provides intense hydration and optimized delivery of actives without leaving a tacky residue.


  • All skin types for early symptoms of photoaging
  • Rough, dull texture
  • Dehydration
  • Discoloration
  • Red blotchiness
  • Skin surface slackening
  • Static and dynamic fine lines


In a 12-week study, Metacell Renewal B3 significantly improved key symptoms of photoaging: clarity, radiance, smoothness, fine lines, and firmness. (1)



After 4 weeks of usage, patients reported satisfaction on all parameters including radiance, pore appearance, skin texture, clarity, and firmness. Patient satisfaction scores increased with continual usage of the product over the 12-week period, not typically observed in patient evaluation.

(1) Protocol: A dermatologist-controlled 12-week clinical on 56 subjects. Subjects applied Metacell Renewal B3 twice daily. Subjects also used SkinCeuticals Gentle Cleanser and Physical UV Defense SPF 30 as needed. Inclusion Criteria: Females ages 40-55 with mild to moderate fine lines and wrinkles, lack of radiance, sallow and uneven skin tone, and rough skin texture.

Key Ingredients

Key Ingredients


5% Niacinamide (with a patent-pending delivery system)

  • Stimulates epidermal cell turnover
  • Reduces discoloration
  • Strengthens skin’s moisture barrier
  • Fortifies skin’s matrix

2.5% Tightening Tri-Peptide Concentrate

  • Highly stable amino-acid chain
  • Supports natural hyaluronic acid synthesis to fill the skin with volume

15% Pure Glycerin

  • Humectant with water-binding properties
  • Provides intense hydration in a fresh emulsion
  • Pro-penetrant – rehydrates flattened keratinocytes, creating a fluid pathway for active penetration without disrupting the skin barrier

Full ingredient list:

Aqua / Water / Eau, Glycerin, Dimethicone, Niacinamide, Propanediol, Dimethicone/Peg-10/15 Crosspolymer, Methylsilanol/Silicate Crosspolymer, Sodium Chloride, Polymethylsilsesquioxane, Phenoxyethanol, Microcrystalline Cellulose, Ci 77163 / Bismuth Oxychloride, Chlorphenesin, Caprylyl Glycol, Sodium Citrate, Ethylhexyl Hydroxystearate, Peg-10 Dimethicone, Disodium Edta, Cellulose Gum, Laminaria Digitata Extract, Adenosine, Citrus Aurantium Amara Flower Oil / Bitter Orange Flower Oil, Melaleuca Viridiflora Leaf Oil, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Linalool, Cymbopogon Flexuosus Oil, Citral, Limonene, Pelargonium Graveolens Flower Oil.

Reviews (24)

24 reviews for SKINCEUTICALS Metacell Renewal B3

  1. Rochelle (verified owner)

    Lightweight and absorbs easily. It gives my skin a radiant glowing complexion. One of my favorites!

  2. Marinda66 (verified owner)

    Best moisturizer for everyday use. I use it morning and evening. It absorbs so nicely and makes my skin feel soft and well hydrated! Love it x

  3. Donna Marie (verified owner)

    If you have combination skin – you might need an extra moisturiser over the autumn and winter months. I went back to triple lipid restore – as this one is more suited for summer, when my skin is oilier.

  4. Tsholofelo (verified owner)

    I just ordered my second bottle and all i can say is a lil goes a long way.My skin texture is slowly improving.After my first use of this moisturize I can definitely vouch for its efficacy.Gets 5 stars from me.

  5. Anna (verified owner)

    This is too beautiful for words, a balance of everything, my skin is always nourished and hydrated, and this also combats signs of ageing too.

  6. Tsholofelo (verified owner)

    I wanted to wait for at least a month before i could give my honest opinion about this moisturizer…..And it works.I love the silky smooth texture,it doesn’t leave your face oily and greasy.I have seen a difference in my skin texture and I love it.A lil pricey but its worth every cent.I use it in conjunction with the the phloretin and this combo im afraid is the holy grain for the texture of your skin.

  7. Carmen (verified owner)

    I’ve been using this product for the last 3 years. It’s lightweight and leaves my skin feeling soft. It also sits well under makeup. It’s especially great in summer time.

  8. Prinasha (verified owner)

    I received a sample of this product and my skin immediately loved it. I bought two bottles after that. It absorbs easily and has such a luxurious feel. Doesn’t leave skin oily yet moisturises so well. Best moisturizer for my skin so far.

  9. Rachel (verified owner)

    This product leaves your skin feeling so soft, silky & smooth! Its texture is a loose silicone feel at first but as you rub it in, it becomes more like an emulsion or lotion which sinks in really well. No horrible product residue feeling after. I love the brighter complexion it gives me & firmness. One less star for me (and a warning to similar skin types) because even though I am the entry / age target for this (looking to start working on anti-ageing products) I do still have very young skin for my age so the firming effect was a bit too strong / not needed for me. I end up alternating every few days with a thicker moisturiser to plump me back up! It’s a great moisturiser & i highly recommend it BUT would suggest that if you have dry skin, I think this product might leave your skin feeling slightly tight, especially if using with retinol.

  10. Perushka (verified owner)

    Wow a great moisturizer that I’m loving on my skin, light weight with no fragrance that doesn’t feel sticky or shiny on my oily skin. I feel hydrated and already see a difference with the clarity of my skin. Will definitely be part of my skin regime, night and day steps.

  11. Donna (verified owner)

    This is like silk on your skin. Great for day and night. At night – can use after retinol. Soaks in quickly. Does not break my skin out – always a deciding factor. Supplies the perfect amount of hydration and skin looks so refreshed after application. Beautiful product all round.

  12. Zeruiah (verified owner)

    Best investment for your skin.

  13. Tasneem (verified owner)

    Love this serum. Sinks into the skin. Calms inflamed skin. Noticed a difference in the texture of my skin after using. Will continue to purchase.

  14. Zeruiah (verified owner)

    This is my second bottle. I have seen an improvement in my skin.

  15. Salisha (verified owner)

    Possibly the best product you can use at night, with Retinol.

  16. Rishana (verified owner)

    Love the product – feels great on my skin and works well with my combo treatments.

  17. Capetown1 (verified owner)

    A lovely satiny finish that has most definitely improved both the hydration and texture of my skin.
    It absorbs easily and works well under my foundation making my skin look healthier and happier all day.

  18. Anri (verified owner)

    Amazing product . Nice silky feeling ,use it as a moisturiser after CE Ferulic in the mornings . Very good base for make up .

  19. Nazmeerah

    This product used in combination with a serum has improved my overall skin texture drastically. It is light weight but still super hydrating. Pricey but worth every single application.

  20. Rochelle (verified owner)

    Light and velvety. Perfect day time moisturizer for my oily skin. My skin looks brighter and healthier.

  21. Bianca (verified owner)

    The SKINCEUTICALS Metacell Renewal B3 Moisturiser has visibly reduced the signs of pigmentation and fine lines that I was looking to get rid off. It has also helped with my ultra sensitive skin, helping take away any redness that I had.

  22. abigail (verified owner)

    I love this product ! I use it in the summer months as my moisturiser. The texture is a silky serum, its stunning. Gives the skin a lovely dewy glow. Love it.

  23. Daniele (verified owner)

    I’ve been using this product as well as the Replenishing cleanser for 3 or so years, I have struggled with my skin for most of my 20’s before trying these products, mostly hormonal acne on the sides of my chin. Those two products in combination with my Claresonic (discontinued) have kept my skin pretty clear. I highly recommend them as well as this website, fast delivery in Gauteng and decent sized samples.

  24. gismo (verified owner)

    5 Start rating! I love this product and I combine it with the serums. I changed over to the Skinceuticals slowly over the last few months and the difference in my skin is amazing. Even though I am 44, I still have oily skin, alternating with periods of tightness and dryness. Well, that’s all in the past now after starting on Skinceuticals.

    • Dr Alek Nikolic

      Hi Gismo thank you for the review and feedback it is appreciated. Kind regards Dr Alek Nikolic.

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Delivered to your door within 1-2 working days after payment is confirmed with Standard Delivery.

Regional Area

Delivered to your door within 3-5 working days after payment is confirmed with Standard Delivery.

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Delivered to your door within 5-7 working days after payment is confirmed with Standard Delivery.

Delivery Options

  • FREE Delivery: On orders above R 750.00
  • Delivery Fee R120.00: On orders below R 750
  • I want to collect? - Collections welcome at our Pretoria office.


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