Brand Focus, Rosacea, Sensitive Skin, Skin Concern

Gentle Rejuvenation System by Obagi

Obagi® Gentle Rejuvenation System for Sensitive Skin

Why Gentle Rejuvenation is ideal for Sensitive Skin Types

For people who suffer from sensitive skin, rosacea, or allergic type skin conditions such as eczema and dermatitis choosing an anti-ageing and skin rejuvenating skincare product poses a special challenge.

We all know that active ingredients in doctor only prescribed skincare products will give far superior results than those found in over the counter products but these ingredients may be a double edged sword for some of us.

“It is known that up to 3% of adults suffer from eczema, 14% suffer from Rosacea, 30% of us suffer from dermatitis, and 44% of adults suffer from sensitive skin”- Dr Alek Nikolic



The more active an ingredient is the more likely it is to cause a reaction on our skins so numerous skincare companies have spent a lot in research and development to find skin ingredients that will have a rejuvenating effect but without causing untoward reactions.

The aim of this article is to highlight two novel ingredients specifically indicated to rejuvenate sensitive and allergic type skin and provide anti-ageing benefits namely Kinetin and Zeatin and their patented Prosome Delivery System.

“Looking at the study results I can highly recommend the Gentle Rejuvenation System for people who are concerned about ageing changes but suffer from Rosacea, Sensitive Skin, and allergic type skin conditions such as eczema and dermatitis”. – Dr Alek Nikolic


Clinical Dermatology – July 2011 • Volume 4 • Number 7


To assess the efficacy and tolerability of a facial serum containing Kinetin and Zeatin  in improving the appearance of fine lines, wrinkles, and signs of photodamage.


Thirty-four female subjects (Fitzpatrick classification I–IV) were examined with early to advanced photodamaged skin were entered into a 12-week clinical trial.


At follow up visits significant improvements in all parameters and skin condition were seen as early as Week 4 however best results were seen by both investigators and enrolled subjects at week 12:


  1. 18% improvement in overall skin appearance by Week 12
  2. Fine lines and coarse winkles improved by 27% and 15% respectively

Significant improvements were also seen with:

  • Pigmentation which was reduced by 10%
  • Skin firmness/elasticity improved by 11%
  • By Week 12 subjects reported a 43% improvement in overall facial skin appearance and 24% reduction in mean scores for facial lines and wrinkles.
  • There was a 71% reduction in erythema (redness)
  • A 94% reduction in skin dryness was seen with 12 weeks use

In my clinical cosmetic dermatology practice treating patients with reactive and sensitive skins has always been a challenge and typically an in depth history of previous skincare regimes and skincare products needs to be undertaken. Interestingly we do find a reason for the skin’s reaction such as an incorrect regime choice: excessive cleansing, using the incorrect cleansing agent (bar soaps), or using harsh scrubs or granular exfoliants or even using an incorrect product for a particular skin type.

At the end of the day it is important that skin reactions are diagnosed by a qualified medical doctor and when necessary medical treatments should be used to get them under control. Once the skin has calmed down my advice is for sensitive skin sufferers to look for ingredients that have been proven to be effective and at the same time gentle and safe.

Kind regards

Dr Alek Nikolic
Obagi® Gentle Rejuvenation System for Sensitive Skin

Gentle Rejuvenation is an ideal choice for patients who have dry Sensitive Skin, and

  • Have the CONDITION of early signs of premature skin aging
  • Are CONCERNED about the appearance of fine lines and wrinkles; want early intervention to address the visible signs of photoaging
  • Are COMMITTED to daily use of gentle, non-irritating products that contain Kinetin and Zeatin but are not yet ready for more aggressive therapies

The Gentle Rejuvenation System for Sensitive Skin Consists Of:

  • Soothing Cleanser
  • Skin Calming Cream
  • Fortified Sunscreen Broad Spectrum SPF 30 with Vitamin C
  • Advanced Night Repair

Key ingredients Kinetin and Zeatin visibly improve the appearance of fine wrinkling, blotchiness and skin texture

Kinetin and Zeatin

Exclusive Prosomes deliver Kinetin and Zeatin into the skin1 and slowly release ingredients over 12 hours. Kinetin and Zeatin are plant-derived growth factors proven in clinical studies:

Noticeably younger looking skin in as early as 28 days

88% of patients stated that their skin tone was more even and clearer, fine lines and wrinkles appeared minimized, signs of aging had reduced significantly

In a national survey: 100% of users were extremely or very satisfied with the products


  1. Dow Pharmaceutical Sciences, Inc. In vitro release of kinetin and zeatin from Prosome Delivery System (study protocol #2875-121). September 12, 2011. OMP, Inc. Data on file.
  2. McCall-Perez F, Stephens TJ, Herndon Jr JH. Efficacy and tolerability of a facial serum for fine lines, wrinkles, and photodamaged skin. J Clin Aesthet Dermatol. 2011;4(7):51-54.
  3. Skin Care Exploratory Final Report, June 28, 2013. OMP, Inc. Data on file

About Dr Alek Nikolic

Dr Alek Nikolic was born in South Africa and received his MBBCh (Wits) in 1992 and in 2000 he received his MBA (UCT). He has been in private practice for 24 years and is the owner of Aesthetic Facial Enhancement, which has offices in Cape Town. Dr Nikolic specialises in aesthetic medicine and is at the forefront of the latest developments in his field. He is very driven and has lectured extensively and has performed live demonstrations throughout South Africa and Internationally including Bangkok, Rome, Paris, Monte Carlo, Prague, and Warsaw. Dr Nikolic’s focus is on skin care, skin ingredients and cosmetic dermatology treatments such as lasers, chemical peels, Botox, and Dermal Fillers. He has performed over 20 000 procedures to date and as such is responsible for training numerous medical practitioners both in South Africa and internationally. Dr Nikolic is one of the founding members of the South African Allergan Medical Aesthetic Academy and chaired its inaugural launch in 2012. The Allergan Academy provides essential training to keep up with the latest technology in aesthetics. Dr Nikolic holds the advisory position of Allergan Local Country Mentor in Facial Aesthetics and is the Allergan Advanced Botox and Dermal Filler Trainer. He is Vice President of the Aesthetic and Anti-Aging Medicine Society of South Africa (AAMSSA) and is an Associate Member of the American Society of Laser Medicine and Surgery (ASLMS).

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